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levels within the central nervous system (CNS), and the temporal relationship between microglial activation and exaggerated cytokine signaling in schizophrenia has not yet been studied in vivo. In parallel, we tested these same individuals for changes in IL 6 levels in CSF and peripheral tissue, along with other markers of peripheral immune response. Through the use of these complementary methods in vivo, we sought to characterize better the neuropathological signature of inflammation in patients with recent onset of schizophrenia.